Preflight, always.
Enroute, my wife and I have a set procedure, I specify how much I want, usually full.
I go close the flight plan, get briefed for next leg, and file new plan, and go to the bathroom.
Wife pays for the gas, and oil if added, and goes to the bathroom.
I shake the wings to settle water at the sump, do a complete preflight, including checking caps on correctly, sumping tanks and gascolater (Most important sump).
Wife returns to plane, we compare expected fuel burn to actual purchase, and we are ready to go.
We were a good team, she took the commercial ground school with me, and passed the final exam with a higher score than many of the pilots in the course. She has flown more than 800 hours of cross country with me.
All the planes that I have flown were tied down outside, and small quantities of water was common, especially after a violent thunderstorm.