340s are great airplanes. They're also pretty solid $500/hr airplanes (according to the Twin Cessna member survey, it's $550/hr average). An SR22 is not even close to that per hour, and certainly not per mile. Compared to a naturally aspirated SR22 you've got turbochargers (2x with an exhaust AD), two engines, and pressurization, all of which add to cost in one way or another. I would say a Twinkie and an SR22 are probably close on operating costs, but no way is a 340 close on operating cost.