I'm not a nutter, so I only need one GPS.
So, after flying for over 20 years with many configurations of zero to five maps, here's what I think is the optimum for normal IFR cross country flying: Two, plus possibly a third, if their capabilities are right.
One of them is the "overview map" that shows you, your destination, and everything in between and has weather on it. Preferably both radar and ceiling/vis. Gives you an idea what you might be running into a couple hours from now, gives you a chance to divert earlier (which takes less time).
The other is the "What's going to kill me in the next five minutes" map. That displays traffic and terrain at a short range, maybe 10-25 miles depending on the speed of the bird.
The other thing that is REALLY nice is a georeferenced approach plate on your panel right next to the PFD. For example, G3000, G3X Touch, or G500 TXi with the screen split into PFD+MFD and showing the plate on the MFD side.
My plane has lost 30 pounds so far thanks to avionics upgrades. I think I can do another 10-15. It's insane how big and heavy some of the old stuff is.
Also, I figured out that my HID and LED light upgrades have lightened the electrical load enough to put a couple horsepower back into the prop instead of the alternator and give me most of a knot back.
Depends on the airplane. Yeah, it probably makes a 172 heavier. A King Air, OTOH, gets hundreds of pounds lighter. Somewhere in between, something probably breaks even.
No, they're not. And you do have to remember buttonology. But if you had a 430 as your primary and you upgrade to a GTN650 but keep the 430 as your #2, you'll probably be OK.
FWIW, the buttonology is very similar on Garmin stuff that's in roughly the same generation. The GNS 430/530 series and G1000 work very similarly. Likewise, the G5000/3000, G500/600 NXi, GTN 650/750, and the GPS 175 and its variants (GNX375, GNC255) all work very similarly as well, so it's not like you're learning something totally new if you have different stuff that's all from Garmin.
The 375 does because it has an ADS-B In/Out transponder built into it. For other GPS units it depends what they're hooked up to.
That's three screens right there.