I maintained my own Jepp subscription for many years, and I do prefer paper. However, I've maintained as many as five full international sets at the same time, and it's a royal pain, especially doing the annual checklists.
We used to have a requirement to dig out all the appropriate books prior to the flight, and also to print a full set of all the departure field, destination, and alternate(s) for every leg. Sometimes that amounts to a LOT of charts.
I'd used EFB's before, but when we got them, I wasn't looking forward to them at all. Formerly, the EFB's I'd had at other operators were unreliable, and I've had two go bad at the wrong time, such as flying into Miami.
For a while, we maintained that all flights had to have printed pages to back up the EFB's, and we went through a fairly exacting observation time with the FAA. In the end, we kept the enroute charts, but the paper terminal charts are no longer on board. The EFB's are mounted to the side of the pilot, hard-mounted to the airplane, but can be removed during a briefing to share with the other crew. The charts can be sent to a printer or another EFB, as well.
I found it awkward to have the chart to one side while trying to fly an approach, but the company standard became a requirement not to use the chart during the approach. Know what one needs to know, and have the other pilot monitoring the approach. The route data should already be on the FMS and on the display, so noting the next step-down altitude, distance to next fix, and so forth, became a matter of focusing more on the instruments and less on the chart. The flight engineer and pilot not flying would do that.
After a while, it became second nature.
I do like the ability to scroll through the procedures without needing to unclip something from a yoke mount; to transition from the arrival to the approach is one touch of the screen. Another touch to go to the airport diagram after landing, and so on. With the alternates pre-loaded, a diversion becomes very simple. The only paperwork to be handled is the flight plan/flight release, and the paper enroute charts, which are still marked up with pen and ink, and a yellow or orange highlighter.
I do like having the paper enroute for two main reasons: it allows looking farther downrange and marking the chart for references, or highlighting frequencies at FIR boundaries. It also makes a handy sunshade.