Deakins has some pretty interesting stuff to say in FAVOR of running a tank dry.
The auxes are the only ones you can safely run dry in the Navion (if you run the main dry you are in BIG trouble). It's no big thing when one runs dry. Hit the boost pump and turn the fuel selector to a tank with fuel in it. The only real embarassing time was when I ran one dry in the middle of a procedure turn while getting my instrument training. The IO-550 in my plane has a bizarre feature that at very low power settings it returns a LOT of fuel into the main tank when running off the aux. I can fly over an hour on the aux tank at normal settings, but at low settings it will run dry in 20 minutes (though it did put 12 gallons back in the main).
I ran one dry on my base leg during my wife's first ever ride in my plane. She knew nothing of the issue but I was very upset. Was the longest restart I've ever had..... talk about nervous.

