I just flew my DA40 home from Vegas to Atlanta a couple of weeks ago. DA40 has lighter wing loading than most 4-seater GA airplanes. NV, AZ, NM, TX are not fun in the heat. Of course most people know that in the afternoons, the convection creates significant turbulence over the desert. So much so that my GFC700 autopilot continually threw error messages and gave up a few years ago on the same route. Not wanting to repeat that rough ride, I left KVGT at 2:00am to avoid getting beaten half to death again. For safety, I just followed the headlights below on I-40 while it was still dark. Means you go a few miles out of the way, but there is always an out if something fails during night flight. After sunrise, I flew more direct. By late morning, I was more than halfway home over Missouri where flying conditions were much more benign. It all comes down to the flexibility in your schedule and route. I highly recommend watching daily turbulence patterns on an app like Windy so you can see what times and routes are most vs least likely to be problematic. If I see an EDR in the red, I'm not flying it. I adjust my route, departure time, or both to avoid the bumpiest areas.