I fly a Cessna340. It has two Garmin 530Ws, a Garmin 345 Transponder, a Garmin audio panel and a Narco DME.
I like the two big gps screens. I select one for navigating and the other for traffic, weather, terrain, etc as necessary. I like the knobs. In turbulence touch screens are tough to use. For IFR the included VOR/LOC was a benefit when I installed the 530s but now a days the preflight briefing includes so many NOTAMs stating the VORs and ILSs are out of service that I basically am forced to rely on GPS. I also have a Foreflight iPad. It eliminates the 60 pounds of paper charts. The 530s do provide most of the data that the foreflight has except for the chartage and approach plates. Once you become proficient with the LPV and the LNAV/VNAV etc approaches you wouldn't hesitate conducting any approach to minimums. That said, I always fly with two pilots, me and Otto or me and a buddy. Someone should always be flying the airplane accurately and someone else should be managing the flight - two different tasks. Otto is my three axis autopilot with altitude hold. It keeps me from busting altitude during cruise. It turns to a vector precisely without overshoot or wandering. It keeps me from chasing the needle on approach. It nails the glideslope or glidepath. I manage the flight and the communications. Don't fly IFR without two pilots. It's just too much work. From my young and stupid days I learned that approaches with one NAVCOM and an ADF was possible but made for really wet underarms. Even then I used a wing leveler.