I know most rentals will be manual, no problem with that, you can't get through high school and college driving a stick unless you learn how to shift with the opposite hand across your body while holding a beverage, burger, and whatever else as you steer with your knees.
I've been told that the visual angles of being on the opposite side of the car do help in reminding you which lane to turn into. My first experience with this was in a cab after a very long flight. The cabbie laughed when I started to get into the driver's seat. But when he pulled out of the lot almost immediately into a traffic circle my jet-lagged self said, "Self, this would have been very bad if you had been driving." I found that cabs were very cost effective compared to rentals - until you wanted to get out of town. After three or four days of cabs and buses I did get the feel and would have felt comfortable giving it a try myself, but not in a city.