San Diego is easy.
Vegas - mostly easy.
MCI - no one else there.
BOS - pretty simple
ORD? Good luck getting C90 to even respond to a call.
SEA - need FIKI and BFI is closer to the city.
. . . they are not all ORD or JFK . .
I'll add that PHL (Philadelphia) is quite easy too.
If you've landed at a class C, it's exactly the same. I think some of the above is making the initial radio work out to be more than it is.
If you're already on flight following with a destination of the main airport, expect approach to ask again for your destination, as it's common practice to initially give FF the name of a nearby big airport so they have a good idea where you're going. So if you're flying from down in North Carolina to Philly, for example, you'll set up "flight following to Philadelphia", and the NC controllers will put PHL in the computer. When you get to Philly approach, they'll want to know if you actually meant PHL, or if you really just meant somewhere nearby.
If you're not on flight following yet, just saying "Philly approach, Bugsmasher XXX, VFR thirty miles to your west at seven thousand five hundred, inbound for landing with [ATIS] Charlie" should do the trick. They might (again) double-check that you want to land at PHL and not somewhere else nearby, but giving them a PHL ATIS up-front should clue them up.
Generally try to take up as little of their mental effort as possible by keeping up a decent and relatively constant speed so they're not guessing about what you'll do next, fly your vectors straight, get the ATIS without being asked, etc. Also be ready for them to ask your destination on the airport, as these generally have multiple FBOs, and the nicer controllers will try to put you on a more convenient runway if they have the time/space.
Also, if you're going in VFR, try to make it on a very good-weather day. I once got stuck trying to come in to Teterboro (not class B, but busy) on a day with broken layers in the 3k - 5k range. Even though that's nothing for us little guys, it meant all of the jets were on the ILS. They were able to sequence me in VFR fine, but I got the impression it was a little bit trickier for them than when all of the jets are on visual approaches.