Kaye:
I flew from KISM up to Greenville, SC over Christmas; then, back down after my visit (IFR). There is a STAR called LEESE One Arrival that's pretty easy to pick up from ALMA (AMG) or Savannah (SAV). They'll bring you in on that and after Ocala (OCF) will begin vectoring you.
Departing to the north, it was vectors to the airway: I went north on V267. They don't like bringing you east until north of Ormond Beach (OMN) because it's on the arrival to Orlando.
VFR you could look at the same general areas. Big restricted area north of Kissimmee; so, you'll need to go just a bit Northeast or Northwest when departing and the opposite when arriving.
Hope you have a great trip. The FBO I used there was Kissimmee Aviation Services. Not as fancy as a couple other FBOs there, but reasonable and fuel was priced right.
Best,
Dave