Used to be a big Quicken fan until they stopped supporting their software on Mac in 2006 and re-wrote it, removing tons of features.
Today it's a mix of spreadsheets, credit union's online tools, mint.com (kinda nerve wracking since they have to have login info to access things, but so far, so good), and have toyed around with MoneyDance but haven't gotten serious with it yet.
On the PeeCee platform, Quicken probably still rules the roost, and if I had to have something it did, I'd fire it up in a VM.
The last two years was mainly an exercise in seeng if I could live without it, and I learned that it is possible to live an Intuit-free life...
Which makes me far happier than having to flip between tools and websites bothers me. Intuit sucks as a company. I voted with my dollars.
Taxes have been relatively simple since I no longer have a mix of ISO shares of an employer along with traditional stock options etc...
(Former employer acquired a company that handled options completely differently than they did, so I had grants of three different varieties at one point. Sold 'em all, which got rid of that problem and their stock dropped out right after I sold -- yay! -- and hasn't recovered, so for once I got something right. Haha.)
... so I've used H&R Block's online system for a couple of years. Really hasn't been at all, and allowed me to eradicate Intuit from my life there, too. No more TurboTax.
Mint has problems with one retirement account, but it doesn't matter much, I just read the statements online and plug stuff into the spreadsheet(s).