It depends on the meds.
Nyquil - no.
Prozac - yes.
More important, you'll need to talk about the condition that prompted the medication. Some conditions may require additional followup work. If all you had was a cold and you took Sudafed, then no problem, everyone has colds. If you had major depression and needed drugs then you need additional testing because the FAA wants to know that the problem is gone.
Additionally, each drug will have time periods that you need to be off it.
Talk to your AME in a consult. If your AME won't do it, hire a new one. Someone will mention Dr Chien as the expert in cases, but you don't need to go to that level unless you know that you're dealing with heavy stuff.
Can you elaborate?