60 Minutes had a good episode on "drones" a couple months ago. One aircraft in the story was a fully automated EMS helicopter. Imagine hopping in the back of that thing at some road intersection with no pilot up front!
I don't see the pilot getting replaced entirely but it's getting to the point where the pilot will essentially be a "robot." I can see a future, at least on the EMS side, where I start the aircraft, put the throttle at fly and then a computer takes over from there. Doesn't seem possible but if a computer can prove that it can fly the profile better than us, companies are going to choose automation every time. When it gets to that point we truly have become systems managers and not real pilots. That's not a future that I'm looking forward to.