Peptites, GLP3 and the like

[k9medic]

I've got a pilot buddy (no, not me or I would have posted anonomously) who has been using peptides and something he calls RETA to manage weight.

It seems like there is a good increase in people using peptites and whatever GLP3 and RETA is for health gains. In my professional career, I have some pilots who I work with that take GLP1 and were grounded for a bit so I've tried to do some digging to see where all of this would impact a Class 3 PPL type of guy.

They are not regulated from what I can find so would the FAA consider this something like a Flintstone vitamin?

 

[Lawson_Stone]

Many of the new diet medications are clearly listed in the medications allowed and not allowed for a Class 3. Maybe check the FAA site.

 

[greentips]

For GLP-1, these drugs are allowed for all classes provided they are for weight loss. The protocol (recent as of 4/2026) is that there are no incapacitation (it is the FAA writing this...) by the condition (overweight), or the side effects and a no fly time of 2 weeks after starting to assure no adverse side effects, and 48 hours after any dose change. You can only be on one GLP-1 or 1 in combination with metformin. Others outside this category are generally not allowed without an SI. The current dispo table is at https://www.faa.gov/ame_guide/media/Weight_loss_Pharm.pdf

 

[Clip4]

The various weight loss medications are being distributed by pharmaceutical companies, compounding pharmacies and what best be described as the rat labs, such as a sites such as True Peptide.

The rat lab sources say the stuff is for research only and not for human use. Many of peptides are not an FDA approved drug and idiots are injecting them using by the suggested doses and side effects provided by sources who explicitly state not for human use.

The Pharmaceutical companies are at war to the compounding pharmacies, who under cut their prices, claiming the formulations have risks for humans. Many of the docs who allow compounding pharmacies choose carefully.

There are risks with LP1s for pilots and just because a person has been on a dose for weeks doesn’t mean they can’t suddenly experience nausea.