I've done the same route fiveish times since early summer, and it's really no biggie. I personally fly it at the suggested altitudes on the back of the TAC and find it to be no big deal as long as you're on your game. Don't get complacent and the extra altitude will be your friend and not your enemy. There aren't tons of great emergency landing spots along the route, and the 600' altitude difference could make your day should something go wrong. For the same reason, you have to look out for traffic flying westbound at 2000'--you can't expect that everyone's following the flyway suggestions.
This is definitely a corridor for GPS use, but there are still enough landmarks on the ground that you could, in theory, make it though solely by pilotage. I.e. without GPS.
Although you're not technically on flight following, some of the controllers will give you traffic reports, which is nice to have. Also, you should be able to keep track yourself of where some of the traffic is based on the radio traffic. Also, going westbound, make sure you get up to 2000' before coming near GAI. 1500' will put your just above their pattern--much too close for comfort, at least for me.
Also, don't be afraid of asking for bravo clearances. The controllers are normally great, and I've had excellent luck getting cleared through the bravo in and out of the western part of the SFRA. I was leaving JYO to the northeast a while back, and I asked nicely for a bravo clearance, and he came back with "Hey, you came to the right guy. Let's see....sure, why not! Cleared into the bravo at 2000'." And another time I was hitting some chop at 4500 on the way back from the Philly area, and I again asked nicely, letting her know I was getting bounced around that high and didn't really want to descend until I had to, and she let me right in. What's the worst they can say? "Unable, stay clear of Bravo." Oh no, scary! Not really
. Now, I haven't tried to ask for it in the corridor, and given that it's right there between DCA, ADW, and BWI, it might be more difficult, but my point is that asking to cut through the Bravo shouldn't be a cause of concern.
Also, I was once going from Clearview 2W2 to Bay Bridge W29. I started off towards MTN, thinking I'd just cut through their delta and turn south towards W29, but then I figured that once the straight line to W29 was out of the SFRA, I'd ask for a Bravo clearance. He came right back with "Cleared into the Bravo at or below 2000 feet." I got to fly right over the Inner Harbor with Baltimore just off my right wingtip! It was pretty fantastic. Maybe something to try sometime?