On normally aspirated engines the mixture should be set for best power prior to landing at high density altitude.
Even at low throttle?
Most of us, particularly in high performance aircraft, operate at low throttle during descent and prior to landing.
What you can do is enrich if it gets rough, but otherwise leave it alone. Maybe give it a little twist in prior to landing, but it's very easy to overdo that
If your POH gives guidance, that trumps, but few of them say much.
If the aircraft has a pressure regulator labeled as fuel flow (e.g., 172RG or 177), you can probably use it at low power the same as high. But if it's a real fuel flow gauge, it will be wrong at low throttle and can't be used for that purpose. That is, I can't just set the 182 to 12 GPH like its best power placard says, 'cause that's for takeoff and presumes full throttle and fine prop.
You may be able to set up a low power cruise to use the cruise tables, but I think you'll be off the bottom, depending on model.