As long as you are charging tach, there's still a big incentive to fly reasonble, even conservative power settings with a wet rate.
I used to fly 2200RPM at cruise in the 182 equity club I was in. This saved me money overall and being an equity club, it saved the club money on fuel and time on the engine, which ultimately saved me money again.
As far as a dry rate, whether LOP operations to save fuel are a concern would depend on the plane. A carbed 182P like I had is going to run rough before you lean it to a dangerous point. In fact, the POH said lean to rough, one turn in for economy, two turns in for performance just like the carbed O-360 birds out there.