I guess to say you've sailed in Death Valley may be worth the endeavor. But you'd need a very shallow draft. Ephemeral lakes are usually very shallow although you could probably get some long tacks. This because the land gradient is very shallow. Water depth at the middle of the lake usually wouldn't exceed 24". And you may very well be 1/4 mile off shore before 10" depth. The trick is to find a channel for your draft. Local knowledge would help...a Ranger would know where to find the channels.
You could wade to the middle of a 2-4 mile wide lake if you didn't get stuck in the mud. That's another thing about the soils out there. Lots of clay, what is termed "fat clay"...hard as concrete when dry; expansive, thick, and sticky when wet. It would be an Ironman feat to trudge very far through that. Getting your boat stuck out there would be a real drag.