I wonder why he flew at such an altitude. The report doesn't mention weather - if I read it correctly.
One reason, with a turbocharged aircraft, might be to get the highest possible TAS; the sales brochures for the SR22 and turbo Mooneys like to give TAS figures at 25k
Was he using the standard cannula, or a mask?
I have done a fair bit of work with o2 stuff
http://www.peter2000.co.uk/aviation/oxygen/index.html
http://www.peter2000.co.uk/aviation/oxygen2/index.html
and while one can go to 20k with cannulas, and I know people who have, doing this requires constant and conscious attention to one's breathing. I use the Precise Flow demand regulator but even having maximum
constant flow doesn't help very much at these altitudes. For example, before doing a long ATC readback, one wants to draw in a long deep sniff of oxygen. It is thus not something I would do with passengers, and a mask is really desirable. And this pilot was much higher.
If he was on a cannula at 25k then IMHO he would have been seriously struggling, at best. One just cannot draw in enough o2 via an open cannula.