I played with Garmin Pilot during the free trial period on my Galaxy Tab 10.1 wifi. It seemed to work well on that platform, and offers a lot of features, but wasn't worth it to me (just a lowly sport pilot) for the price once the trial expired. I can definitely see how it could help in more intensive operations.
I now use Naviator, which - while lacking some of the features and polish of the Garmin - also works very well on my Tab. The GPS signal is steady and accurate, and doesn't seem to use an inordinate amount of battery.
The 10.1 is a bit large for an LSA cockpit with two people onboard, but as others have mentioned the larger size is nice for readability, and is beneficial in normal use away from the airplane. I've been very impressed with the Galaxy Tab; when wifi isn't available I use my Galaxy S2 cell as a mobile hotspot.