I'm a fan of the Twinkies and I've probably looked into buying them more than any other type. However, I've only flown one and haven't owned any.
The gotcha that's mentioned most is the landing gear bungees. I believe there's an AD on them... But I'm sure you know where to find that info.
Corrosion is generally not a problem on the Twinkies.
1966 was the first year of the "B" Twinkie. It's easy to tell the difference from the A, as the B and C have a third side window and some of them have six seats (the last two pretty much entirely eat up the baggage compartment.) Shotgun panel was standard until 1969. B and C models were also available in a turbocharged variant which came from the factory with tip tanks and oxygen.
Miller mods (200hp engines, modified nacelles with wing lockers, dorsal fin, long nose with baggage compartment) will fetch a premium both when buying and when selling. They are no longer available.
Tip tanks are a popular and worthwhile add-on. MGTOW is increased by 125 lbs, and that entire 125 lbs must be fuel in the tips, but it's quite easy to simply leave the aux tanks empty and fill the tips instead to get a "free" weight increase.
Other mods that are still available include speed mods (cowls, aileron and flap gap seals, gear lobes), counter-rotating mod (replace 1 engine and prop, effectively making it a PA-39).
Mods that I think are still available but I'm really not sure: One-piece windscreen, STOL kit, and small nosewheel mod (which keeps it from wanting to fly itself off below Vmc, and I've heard also makes it easier to land).
Obviously, you can mod the heck out of these birds.
There are a couple of Twinkie owners on the boards, Ryan Ferguson and Charlie Melot come to mind.
IMHO, you can certainly do a lot worse than a Twin Comanche. It'll perform slightly better than a 201 and give you the advantages and "cool factor" of the twin. Fuel burn will be increased, but not by a lot. Range, especially with the tip tanks, is outstanding. Not too many gotchas, and in general they're doing quite well for their age.
BTW, when you re-do the panel, consider the Garmin 600. You'll end up converting the "Poor man's Baron" into the "Poor man's TwinStar."
Lots more info online:
http://en.wikipedia.org/wiki/Piper_PA-30_Twin_Comanche
http://www.fergworld.com/twincomanche/
http://www.comancheflyer.com/the-comanche-story.php?story=PA30_39