Danny,
I have flown a glass SR22 a few times, but I don't do it routinely. They open up an amazing amount of awareness and capability. There is also every indication they will be more relliable in the long run than mechanical gauges. However, they also push you more in the direction of systems management, which you may or may not like. The more advanced systems may take more effort to retain proficiency, or they may take less. I don't have enough experience with them to know. But I think it says something that in the Cirrus there is a checklist to keep track of your checklists.
....