COVID Vaccine

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Interestingly the same people who complain about potential long-term health effects of a COVID vaccine seem to completely ignore the already proven potential long-term health effects of COVID.

Cognitive dissonance on full display for all to see.
 
Interestingly the same people who complain about potential long-term health effects of a COVID vaccine seem to completely ignore the already proven potential long-term health effects of COVID.

Cognitive dissonance on full display for all to see.
Death being a particularly long-term effect. Just found out that my 80+ in-laws are infected. So far, very mild.
 
Doesn’t matter. You don’t want ANY chance of TM for a vaccine against a 99% survivable virus. Been in multiple TM groups since my misdiagnosis. Want hell on earth, get diagnosed with TM.

Symptoms of my disorder are nearly identical and I’m waaaaaay into the low-symptoms / lucky side of those, and I was headed for a wheelchair. And mine was treatable. TM usually isn’t.

That’s one big damn “nope” right there. Just as the Professor said. Screw that.

Even a chance of triggering an autoimmune reaction that attacks the central nervous system, to feel happier about a 99% survivable disease, is pure unadulterated and undeniably stupid.

Stick to the ones that don’t do that.
Nate, get with the program. There's MONEY TO BE MADE and (political) careers at stake, don't you know!

:D :D :D
 
A couple I know volunteered for the Moderna trial, which is double blind, of course. She got symptoms (swelling and soreness at the injection site, a tiny fever briefly) while he didn’t. Pretty obvious who got the placebo, although it probably doesn’t matter.

They’re newly retired and spend all their time together, so they’re kinda perfect for the trial. Except that they don’t risk going out, so neither will get infected anyway.
 
Doesn’t matter. You don’t want ANY chance of TM for a vaccine against a 99% survivable virus. Been in multiple TM groups since my misdiagnosis. Want hell on earth, get diagnosed with TM.

Symptoms of my disorder are nearly identical and I’m waaaaaay into the low-symptoms / lucky side of those, and I was headed for a wheelchair. And mine was treatable. TM usually isn’t.

That’s one big damn “nope” right there. Just as the Professor said. Screw that.

Even a chance of triggering an autoimmune reaction that attacks the central nervous system, to feel happier about a 99% survivable disease, is pure unadulterated and undeniably stupid.

Stick to the ones that don’t do that.
Not disagreeing with you. Especially with what appears to be a lack of transparency in those cases. You've good reason for concern. I'll only note that the citation mentioned they don't know whether those cases got the vaccine (very worrisome), or the placebo.
But the company and the University of Oxford have yet to say whether the two participants received the vaccine or a placebo.
 
Interestingly the same people who complain about potential long-term health effects of a COVID vaccine seem to completely ignore the already proven potential long-term health effects of COVID.

Cognitive dissonance on full display for all to see.

Tons of us already have long term medical conditions that aren’t fatal. You’ll have some too in a few more years. Very few make it out of their 40s without one.

The exact opposite of cognitive dissonance.

More like complete lack of experience on the part of those worried about it, who likely already have 50% blockages in coronary arteries from their diets, or are well into major liver damage from heavy drinking without symptoms yet that won’t show up as symptomatic or be tested for, for another ten years.

Ah yes, the young and invincible crowd whining they might have detrimental effects from natural causes. I remember when I thought most people were healthy, too.

Whole bunch of us who aren’t significantly concerned about adding to the list of stuff we’ve survived. Check engine light turned on a long time ago for many.

Watching you youngsters with no experience with it “warning” all of us about it, like we haven’t taken bigger risks to get where we are today, is kinda precious though. Haha.

“But but but illnesses might hurt you!”

“No s***? I didn’t know. Boy am I glad you mentioned it like thirty times.”

LOL.
 
And how many of those long-term medical conditions are caused by something that is completely preventable if people weren’t so obtuse?
 
Is that the one from the UK being investigated as a possible source of Transverse Myelitis in two patients that was fully halted?
When I heard that on the news (at least a month ago?) I thought I recalled that was your condition. Never heard of it before your thread.
 
Not disagreeing with you. Especially with what appears to be a lack of transparency in those cases. You've good reason for concern. I'll only note that the citation mentioned they don't know whether those cases got the vaccine (very worrisome), or the placebo.

Thought I had read that they decided to “unblind” the test for those patients, in order to investigate, but maybe that’s not accurate or how it works. I suppose you’ve also signed away your ability to sue for damages in these trials, but never looked into it.

TM, at best, is usually so called “manageable” neurological pain for life, and some level of disability. At worst is fully paralyzing in less than three days. I did read one patient was at least paralyzed to the paraplegic level. Not good at all.

Two or more just suddenly being diagnosed with TM, as incredibly rare as it is, in the tiny numbers in the trial... is very mathematically unlikely not to be from the vaccine. TM isn’t as rare as my disorder but it’s still incredibly rare.

(Even rarer in the last couple of decades as they’ve peeled other disorders out from under the TM “catch all”, like finding a test for Neuromyelitis Optica and categorizing a couple of rare forms of MS. Wasn’t even a quarter of my lifespan ago they just called all of those, TM.)

The general knowledge today that it’s linked in some way to an out of control immune system reaction that decides healthy neurons are the body’s enemy, also points pretty squarely to it being extremely unlikely they received the placebo. Jacking with the immune system would naturally be linked to an out of control immune system reaction.

Irony. Trying to ward off an extremely rare out of control immune system reaction, they likely triggered a normally even more rare one.

More irony: Not proven as causation, but far too many TM patients have reported recent vaccinations for other things just prior to onset of symptoms. They just can’t find a specific link.

And it’s not anywhere near every patient, so there’s multiple paths to TM, probably a bad reaction to an immunization being just one of them.

I like to joke that there’s certain people we don’t want to taunt their immune system. Their immune system will happily and immediately try to kill them. Heh.

Pretty interesting stuff. But going to go cook up some red meat now and die of that probably. It’s steak night. :)
 
One of my friends in town, mid 40s guy who worked for Trail Mix (hikes mountains for a living) and likes to run marathons now cannot walk up a flight of stairs without getting winded 6 months after he got COVID. I do not want any part of that.
 
Thought I had read that they decided to “unblind” the test for those patients, in order to investigate, but maybe that’s not accurate or how it works. I suppose you’ve also signed away your ability to sue for damages in these trials, but never looked into it.

TM, at best, is usually so called “manageable” neurological pain for life, and some level of disability. At worst is fully paralyzing in less than three days. I did read one patient was at least paralyzed to the paraplegic level. Not good at all.

Two or more just suddenly being diagnosed with TM, as incredibly rare as it is, in the tiny numbers in the trial... is very mathematically unlikely not to be from the vaccine. TM isn’t as rare as my disorder but it’s still incredibly rare.

(Even rarer in the last couple of decades as they’ve peeled other disorders out from under the TM “catch all”, like finding a test for Neuromyelitis Optica and categorizing a couple of rare forms of MS. Wasn’t even a quarter of my lifespan ago they just called all of those, TM.)

The general knowledge today that it’s linked in some way to an out of control immune system reaction that decides healthy neurons are the body’s enemy, also points pretty squarely to it being extremely unlikely they received the placebo. Jacking with the immune system would naturally be linked to an out of control immune system reaction.

Irony. Trying to ward off an extremely rare out of control immune system reaction, they likely triggered a normally even more rare one.

More irony: Not proven as causation, but far too many TM patients have reported recent vaccinations for other things just prior to onset of symptoms. They just can’t find a specific link.

And it’s not anywhere near every patient, so there’s multiple paths to TM, probably a bad reaction to an immunization being just one of them.

I like to joke that there’s certain people we don’t want to taunt their immune system. Their immune system will happily and immediately try to kill them. Heh.

Pretty interesting stuff. But going to go cook up some red meat now and die of that probably. It’s steak night. :)
While you are likely correct they didn't get the placebo, I've seen enough coincidences that I'm not willing, with the little information available, to blame the vaccine as yet. I agree it is pointing that way.
Enjoy your steak!
 
Not understanding or refusing to acknowledge something is the very definition of obtuse.

May want to look it up.

Usually only the former not the latter, but as explained, everybody here fully understands your “warning” just fine. Not exactly a dumb crowd.

There’s no mathematical path in the US at this point that isn’t at least linear growth until vaccine (still unlikely and nearly impossible to distribute in any quantity for at least another year by simple logistics math for 230M-ish — thats leaving off 100M who simply won’t be interested in the slightest) or herd immunity.

It’s gonna just keep on rolling. Make your personal decisions about what you’re doing for you, at any time.

Forced lockdowns in the worst hit rat colonies won’t survive a second attempt. They already shot that wad. Doesn’t matter what you or I think about it, civil disobedience will kick in. Definitely won’t survive past the winter into spring.

Too much ineptitude on the rules and too many flip flops. And definitely not enough actual math or science being proffered. People simply won’t comply after all that, good or bad. Way too many with bigger problems now.

Just the way it goes.

Very few are actually obtuse. They’re just pretending to be to see a rise out of you or to get you to go away quicker.

The reality is, they’ve made it to the last stage of grief and made their decisions already. New significant data? Maybe some new decisions. Maybe not.

You complaining it might happen to you if they go about their lives? They definitely don’t care. Not because they’re heartless, they’re just playing the cards they were dealt.

That’s just the reality of it, my young friend. Complain all you like, they’re not interested.

They totally get it though. Not obtuse at all.

It’s nice that you don’t want to catch it, but still generally meaningless when it comes to the math of it. Sorry.

Our 80+ year old MIL isn’t complying with jack anymore. She’s not exactly going to blame herself if you catch a virus either. She just has weighed the options and decided for her. If someone else wants to hide from it, she’s fine with that. Many did through the multiple other diseases she’s seen. She also realizes what I said above is true.

She moved out of her ridiculously locked down senior living facility a few months ago. Guess what facility has out of control Covid in it now? And still hasn’t evacuated. The place she left.

Dumb. Really dumb. We have solid math on this.

It was always going to get in. All the residents knew that in April. Being locked in their rooms and delivered mass quantities of alcohol was never the correct solution. When she found out they were lying about having been in touch with local health authorities, that was her cue to move.

So... When you add up the percentage who don’t care if you get it, and the percentage with bigger life problems altogether, it’s a solid majority.

Maybe they’ll die, maybe they won’t. Maybe they’ll have lasting effects, maybe they won’t.

They get it. They aren’t obtuse.

They probably do ***act*** obtuse toward someone they know would freak about their honest opinion, though. If you’re exuding the freak out vibe, they smell that a mile away.

They’ve seen it, and watched it lead nowhere useful — lots more times than Covid. They’ve had enough of that for a lifetime.

No time or energy left to coddle anybody thru it anymore.

They figured out life ain’t fair about six dead friends of cancer ago. Your stair climbing buddy huffing and puffing is super tame, compared to where they’re at in life.

For others, as opposed to the MIL, they’ll be hiding for however long it takes. Probably years. My mom probably falls in that category. We’ll hear she died in that house, before she’ll have anybody over again. Her call.

We’re fine with both of their decisions. Doesn’t matter what we say anyway, powdered butt syndrome.

Good call on the use of the word though.

Miriam-Webster says the now very common use, meaning “difficult to comprehend”, probably came from misuse of the word instead of abstruse. Neat. It morphed.

I rarely hear anyone use that one properly and always hear it used in the new way.

(Well, I usually hear it used more in relation to angles and degrees than either other way... engineering lifestyle and friends and such.)

Anywhoo. Whole bunch of people who aren’t obtuse, they’re just going to act like they are when presented with your story of “I don’t want any part of that.”

Okay then, change your life so you don’t.

That’s what they’re really thinking.

Your buddy is now a member of the club.

People you yell at that he got sick and has issues from it, who probably act ... obtuse:

- Buddy from a hobby who lives just up the dirt road has been on 10L of O2 or more for a couple of years now. Best guess is he has some crazy thing like MS that makes his lung tissue and muscles not work right. They haven’t figured it out yet. He’s seen a pile of specialists. Another round starting at the University now. He took the family and did multiple states in an RV this summer — figured he may not be around next summer to do it with the kids. Couldn’t care less about Covid. Guess where his wife works? Covid ward. Not kidding. He made his peace with it a really long time ago.

- Good friend and co-worker got news his brain tumor is back. Another surgery and a couple of months of daily radiation. Looks like he’ll have to move himself, his SO, and his dog to another state for those two months. Friends may have figured out how to deal with his house and his cat. Have a gofundme for his expenses going if you feel like donating. Used to fly gliders. Got the same info I did from the medical pros. All the meds he’s on were a concern at first. Maybe high risk. Numbers didn’t hold up for that and even pushed us both into low risk for the wild reactions. We both aren’t going out of our way to catch the thing, but we both have medical and other stuff to do. If a Doc, especially a Mayo Doc says travel, we travel. Covid or no Covid. He was there last week.

- Another old friend got diagnosed with as rare a disorder as mine (maybe more) that attacks small tissue skeletal muscles. He won’t be alive for too many more years and won’t be able to move at the end. Heard about that one this morning. Karen went to grade school with the guy. I met him in high school and followed his photography career ever since. He won’t make it out of his 50s. Going to guess he’s not too concerned about Covid. He’s going to be human Jell-O in less than a decade.

- Best friend from high school has rheumatoid arthritis bad enough he’s seeing the infusion docs once a quarter. Lonely drugs. Great side effects. Covid is pretty much a novelty for him, other than it closing his line of work down, maybe permanently. Certainly for a very long time. Catching it isn’t his biggest concern by a long shot.

- Former CFI of mine still fighting that tumor in his neck that’s inoperable. Doubt he’s thinking too heavily about Covid.

- Too many women who’ve had breast cancer in Karen’s chorus to even count. Two who chose preemptive double mastectomies. Genetics. Yay. Cancer has killed two more of our friends this year than Covid, and accelerating. Three others diagnosed. Looks like we’ll start our 50s with a couple more funerals.

There’s just a whole lot of folks out there who will be out doing wherever they need to, or want to, and won’t be too interested in someone “warning” them they might catch Covid during Covid — or that illnesses cause other effects.

They’re already years ahead down that path. Accepted it a long time ago.

Those are just the medical examples in my life.

Anyway.... if ya really want to get out of that dangerous airplane biz, come on out for a visit. Can teach ya how to be as non-essential as me. Ha. Jr Sysadmin classes. Can even teach via video if you want. But a whiteboard is easier. Probably not quite as satisfying as Medevac but you won’t catch Covid. If you do it’ll be from Karen and we can give her crap for being essential. LOL.

Very few you meet are truly obtuse though. They’re just not bothering telling you the truth.

They already calculated their life problems and Covid isn’t even on their top-ten list. Wasn’t when it started and won’t ever be.

That it’s on your top-ten worry lost because a friend had side effects? They’re like, “Hell. Side effects were happening to my friends ten years ago. Way more than one, too. We’re waaay past that. Been to multiple funerals. You’re warning us about side effects from a virus? No offense, but that’s super cute, kid. We remember the first friend who got seriously ill, too. Ten years ago. She’s been dead for years.”

But that’s way too long and boring and anybody in freak out mode doesn’t want to hear it anyway. Make ya cranky. It once did us, too.

Far easier to play dumb and chuckle and ask the other oldsters privately, “Remember when we were all scared of X? He reminds me of us back then. Nice kid. Bummer about his buddy. How’s your brain tumor?” LOL.
 
Last I checked brain tumors and arthritis weren't contagious.

The insanity about this covid thing is if people had taken it seriously from the start it would be over by now. Instead, folks who have to aggressively tell us how ignorant they are deem masks tyranny and a violation of their personal freedoms. I've seen plenty of COVID. I've never flown someone with a tube down their throat because they have the flu, but I have plenty with COVID. Our local ICU is full of COVID, our state is at 80% capacity of TOTAL beds; the majority occupied by people with COVID. Everyone who wants to live their lives in ignorant bliss should have to sign a waiver so they don't divert critical medical infrastructure away from people who haven't been selfish ********s from the start.
 
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Last I checked brain tumors and arthritis weren't contagious.

The insanity about this covid thing is if people had taken it seriously from the start it would be over by now. Instead, folks who have to aggressively tell us how ignorant they are deem masks tyranny and a violation of their personal freedoms. I've seen plenty of COVID. I've never flown someone with a tube down their throat because they have the flu, but I have plenty with COVID. Our local ICU is full of COVID, our state is at 80% capacity of TOTAL beds; the majority occupied by people with COVID. Everyone who wants to live their lives in ignorant bliss should have to sign a waiver so they don't divert critical medical infrastructure away from people who haven't been selfish ********s from the start.


Nature gonna nature.

Isn't it selfish to impose how you want other people to live their lives? Oh wait, that's different because it's you getting what you want. Got it.

Get busy livin' or get busy dying.
 
"If people had taken it seriously from the start it would be over by now."

So when did it start, exactly ?
 
Looks like Moderna knocked it out of the park.
 
Moderna just unblinded the results of their vaccine trial, and the preliminary analysis shows it to be 94.5% effective. Final numbers may shift a little, and we don't know if this is better than Pfizer's vaccine, since they only reported >90% efficacy.

Both the Moderna and Pfizer vaccines are built on the same technology, so they were expected to behave similarly. Both require two injections about a month apart, which isn't ideal, but there are plenty of single-shot vaccines coming up through clinical trials. The Moderna vaccine is a little more temp stable...it has to be shipped and stored at -80C, like the Pfizer vaccine, but it can be thawed and stored in a refrigerator for almost a month, which simplifies getting it to patients.

Unlike Pfizer, Moderna has no manufacturing capabilities, but contract manufacturers have been freeing up capacity for months now, in anticipation of making something. I'd expect Moderna to file for their Emergency Use Authorization within days, just as Pfizer did.

Neither will make much of a difference this year; they'll be doing well to get a few million people vaccinated by the end of December, but it's a start.

Moderna vaccine results
 
Yes, obtuse, as in anti-science conspiracy morons.

Ringing any bells?

I trust science and scientists, what I don't trust is their management. Whoever is 1st to market stands to make obscene amounts of money, and visions of the almighty $ encourage management to be less than ethical in behavior.

I won't be a 1st adopter this time out...
 
I trust science and scientists, what I don't trust is their management. Whoever is 1st to market stands to make obscene amounts of money, and visions of the almighty $ encourage management to be less than ethical in behavior.

I won't be a 1st adopter this time out...

It's true, this will be huge for whatever companies get to market first...but, the current frontrunners not only need storage at -80C, they require two shots. Follow-on candidates in the clinic have none of those limitations--and at least one is an oral dosage form. So I'm confident in predicting that the best-selling vaccine a year from now won't be either of these early successes.

As for early adoption, I will happily take the vaccine when it is available to me. I must qualify that by saying I'm not in any category that will make me a high priority for dosing. So in that respect, I'm fortunate that I won't have to make the call based on short-term efficacy and safety data from the 15,000 people in the treatment arm. I don't think I'll be able to get the vaccine until 2Q2021, and by then there will be data for millions of recipients, in many cases spanning 6 months or more. So if it is still looking good then, hell yes, I'm in.
 
I trust science and scientists, what I don't trust is their management. Whoever is 1st to market stands to make obscene amounts of money, and visions of the almighty $ encourage management to be less than ethical in behavior.

I won't be a 1st adopter this time out...
Just look at what happened when the FDA allowed companies to "self-certify" their covid tests earlier this year. Or, closer to topics for an aviation board, the FAA reduced oversight on Boeing and how well that worked out for the 737 MAX.
 
Just look at what happened when the FDA allowed companies to "self-certify" their covid tests earlier this year. Or, closer to topics for an aviation board, the FAA reduced oversight on Boeing and how well that worked out for the 737 MAX.

Even with government oversight I'm still a bit skeptical. This is, after all, the same organization that foisted the "food pyramid" on people, 6-11 servings of grains per day (and the vilification of fats and proteins) are why obesity and diabetes runs rampant in the US.
 
I trust science and scientists, what I don't trust is their management. Whoever is 1st to market stands to make obscene amounts of money, and visions of the almighty $ encourage management to be less than ethical in behavior.

I won't be a 1st adopter this time out...

Anyone with a vaccine that works, is safe and can get approval will make a metric s%%%-ton of money as demand for the vaccine will outstrip supply for a long time.
Of course, now that BioNTech and Pfizer beat Moderna by a few days, we will remember them for the achievement. With a slightly longer view, the few days difference is not going to affect the success of the respective companies. Now its down to getting the production spooled up and the logistics in place to get this stuff into every nursing home, assisted living facility and bowling alley.

Oh, and I hope they make a ton of money. Without that incentive, we wouldn't see those types of advances.
 
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Anyone with a vaccine that works, is safe and can get approval will make a metric s%%%-ton of money as demand for the vaccine will outstrip supply for a long time.
Of course, now that BioNTech and Pfizer beat Moderna by a few days, we will remember them for the achievement, with a slightly longer view, the few days difference is not going to affect the success of the respective companies.

Oh, and I hope they make a ton of money. Without that incentive, we wouldn't see those types of advances.

As long as they prove safe near and far term, yes.
 
The illnesses seen in the Astra Zeneca trial (also one seen in the Johnson and Johnson trial which uses similar technology) are a bit puzzling. Given how quickly they came out I doubt it has anything to do with the vaccine, I suspect those disorders already existed in those folks and became active during the trial. They are the sort of autoimmune illness I predict the viral based vaccines will cause, if I'm right. I predicted the first gene therapy trials would kill people and damn if I wasn't right. By the way, the Russian Sputnik vaccine is also based on the viral vector technology and has been administered throughout Russia. By Odin do I hope I'm wrong.
 
It's true, this will be huge for whatever companies get to market first...but, the current frontrunners not only need storage at -80C, they require two shots.

The cold storage is less of an issue that it may seem on first glance. Pfizer is planning to deliver it in a cooler with dry ice that is good for 10 days (15 days with a top-off of dry ice). After thawing, the vaccine is good for 5 days. Shipping on dry ice is a mature technology, unless the government gets involved in the distribution, I dont see a risk of vaccine going to waste.
 
I believe everything I hear on the radio </sarcasm>

I listed a source, I heard it and verified it .... surely you're not that obtuse?

Depending on the trial, that person probably doesn't know what injection they were given. Maybe had a reaction to the placebo.

Moderna results are out this morning ... won't do your leg work for you, but there is an "inflammatory response" at the second dose administration, but twist that however you like ...

There was no need to inject any names, and that is what made it political. The inclusion of the names did nothing to support or refute whatever point you were trying to make.

I'm apolitical ... you already have the next administration stating 75 years old is plenty of years. The ACA won't list this as a "cut-off", but the panels that decide for your region have been using it for years (see if you can get CABG or a joint replacement after 75 in your area). If you think Obamacare changing to Bidencare is going to help, goo luck. I work in the medical field (non-physician) and get exposed to Covid several times a week, but I do appreciate your arm chair QBing telling us in the field how things are working and are not political:confused::confused::confused::confused::confused:
 
Since I’m 99% certain I got the Moderna Vaccine in the trial, their latest news is great. So far after getting both shots around a month ago, zero side effects except the soreness in my arm and shoulder for a few days after the injections.

If the vaccine eventually turns me into a vegetable or I grow a third eye in my forehead, I’ll have someone update the thread.

Cheers
 
k. well, I'm still not getting either shot. I hear when some people get the flu shot they actually get the flu. but wtf do I know.

No. People do not and cannot contract flu from a flu shot. The vaccine does not contain viable virus. Vaccines contain materials (inactivated virus, virus protein, or mRNA coding for viral proteins) that provoke the immune system to produce antibodies and memory T-cells to protect you from exposure to the targeted infectious agent in the future. Some individuals will experience side effects due to the ramp-up of your immune system to react to the vaccine antigens. This is normal and usually quite tolerable.

There is no real reason to avoid the vaccine unless you are immunocompromised. While most COVID cases do not cause death or long-term morbidity, about 1-3% of individuals who test positive will die. Dying, being so irreversible if you are one of the unlucky ones, is a good fate to avoid.
 
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The initial, promising results for both Pfizer/BioNTech and Moderna has vindicated the science behind it, from both the basic research that made this approach possible at all, to the technology required to deliver it in an effective form. These efforts are a tour de force of chemistry and molecular bioscience. Having been in this field of teaching and research for 35 years doesn't make it any less impressive. The Phase III trials have echoed information gleaned from Phase I trials and primate studies. So I am more than cautiously optimistic. Durability of immunity is another issue, but that can be successfully addressed later.

I was lucky enough to have enrolled in the BioNTech trial, and based on my post-dosing symptoms, I'm 99% sure that I received the experimental dose and not the placebo. At any rate, it appears likely that BioNTech will seek to unblind the trial after receiving the EUA, which is expected in late November or early December, when a sufficient number of dosed patients have reached the 2 month mark after the second dose without significant long-term effects. At that point, if the feds approve modifying the study, volunteers receiving the placebo will be offered the vaccine. The downside of being in the trial is that if you so much as come down with sniffles, you get an RT-PCR Covid test. (Actually, two tests: one for the study, and a community test for your own knowledge.) At this point, I have had more nose swabs that I care to relate. But it's good to contribute to science.
 
I listed a source, I heard it and verified it .... surely you're not that obtuse?
It's a BS source. I explained why



Moderna results are out this morning ... won't do your leg work for you, but there is an "inflammatory response" at the second dose administration, but twist that however you like ...
Probably the same as what you get from a flu shot. You make an assertion, you provide a citation.


I'm apolitical ... you already have the next administration stating 75 years old is plenty of years. The ACA won't list this as a "cut-off", but the panels that decide for your region have been using it for years (see if you can get CABG or a joint replacement after 75 in your area). If you think Obamacare changing to Bidencare is going to help, goo luck. I work in the medical field (non-physician) and get exposed to Covid several times a week, but I do appreciate your arm chair QBing telling us in the field how things are working and are not political:confused::confused::confused::confused::confused:
"Apolitica", right. You going to sell me a bridge next? I don't what the comments above have to do with this thread.

The people who mop the floors in a hospital and keep things clean do an important job, and they work in the medical field, too.
 
The initial, promising results for both Pfizer/BioNTech and Moderna has vindicated the science behind it, from both the basic research that made this approach possible at all, to the technology required to deliver it in an effective form. These efforts are a tour de force of chemistry and molecular bioscience. Having been in this field of teaching and research for 35 years doesn't make it any less impressive. The Phase III trials have echoed information gleaned from Phase I trials and primate studies. So I am more than cautiously optimistic. Durability of immunity is another issue, but that can be successfully addressed later.

I was lucky enough to have enrolled in the BioNTech trial, and based on my post-dosing symptoms, I'm 99% sure that I received the experimental dose and not the placebo. At any rate, it appears likely that BioNTech will seek to unblind the trial after receiving the EUA, which is expected in late November or early December, when a sufficient number of dosed patients have reached the 2 month mark after the second dose without significant long-term effects. At that point, if the feds approve modifying the study, volunteers receiving the placebo will be offered the vaccine. The downside of being in the trial is that if you so much as come down with sniffles, you get an RT-PCR Covid test. (Actually, two tests: one for the study, and a community test for your own knowledge.) At this point, I have had more nose swabs that I care to relate. But it's good to contribute to science.
I agree. I’ve had enough “brain swabs” and blood draws to last my lifetime.
 
The illnesses seen in the Astra Zeneca trial (also one seen in the Johnson and Johnson trial which uses similar technology) are a bit puzzling. Given how quickly they came out I doubt it has anything to do with the vaccine, I suspect those disorders already existed in those folks and became active during the trial. They are the sort of autoimmune illness I predict the viral based vaccines will cause, if I'm right. I predicted the first gene therapy trials would kill people and damn if I wasn't right. By the way, the Russian Sputnik vaccine is also based on the viral vector technology and has been administered throughout Russia. By Odin do I hope I'm wrong.

The viral vector vaccines probably have a greater risk of adverse outcomes than the inactivated whole virus, mRNA or protein subunit based vaccines, due to the presence of the "live" viral vector. (Actually, they are all highly genetically modified virions that cannot reproduce themselves, but can perform the important function of introducing genes coding and production of target antigens in cells.) In addition, future dosing with a viral vector vaccine may result in diminished effectiveness if your immune system raises antibodies and memory T-cells against the viral vector. This will not be an issue with whole virus or small-molecule vaccines.
 
Moderna just unblinded the results of their vaccine trial

I do not believe they can unblind their trial until they apply for and are awarded an EUA. And they would have to apply to modify their current study to unblind it and offer vaccine to placebo volunteers. (That is the ethical thing to do if in fact it is effective.) Until that time, the experimental groups of volunteers will be kept double-blind. BioNTech is hinting to participants that they may apply for unblinding their trial.

What Moderna has done (as BioNTech did last week) is take a peek at anonymized data for a limited set of volunteers who contracted Covid to see if there is a statistical difference between the experimental and control groups among the sickened individuals. They will continue to peek at this data until they accumulate enough sick patients to justify an EUA, which is in the neighborhood of 150-200 sickened individuals, depending on the study.
 
It's a BS source. I explained why

You're trying to combine two issues with minimal knowledge of either ...

Probably the same as what you get from a flu shot. You make an assertion, you provide a citation.

Probably, but still won't do your own leg work checking sources ... as usual.

"Apolitica", right. You going to sell me a bridge next? I don't what the comments above have to do with this thread.

Actually yes ... Biden's son as well as McConnells wife should both be investigated to start. Guess you're the type that only believes in investigating one party .... I'm the type that would love to see a decent insurance again that doesn't cost 30K a year for family insurance.

The people who mop the floors in a hospital and keep things clean do an important job, and they work in the medical field, too.

Yes they do, and why you decide to denigrate them and place yourself on a pedestal shows your true style ...
 
Thread closed pending MC review.

Edit: The thread will remain closed per MC vote.
 
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