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So if the air has a high density, less molecules of oxygen available because of increase in temperature, there would be fewer available to be heated or cooled to normal body temperature, and not as many for the transfer to the blood. So then is density not a factor with hypoxia?

So you are saying that our bodies do a better job than the engine at maintaining a constant temperature. That being said density (pressure + temp) is not a factor and hypoxia is only affected by pressure altitude. Our engines need a hypothalamus?

I was wondering why a naturally aspirated engine is affected by density altitude but hypoxia is only affected by pressure altitude. Why would lungs not be affected by density? Thank you