I agree with flying to get there quickly but I would add comfort and that straight lines are not always the fastest. My experience has been the prevaling winds when I have flown have been the most favorable the KREI LAS KEKO direction either because of a tail wind or winds over the mountain...
Fly to LAS then stay to the east of the restricted areas and go straight up the valley. I would not go IFR with the planes you mention because the airways will take you out of the way and the MEAs are very high. If it is windy and you get a lot of turbulence up high get down on the deck a...